Studies have shown that in the concentration range of 5–10 μM, C:26 could significantly increase the level of ROS and decrease the level of GSH in ABCD1 gene knockout oligodendrocytes and X-ALD fibroblasts, and the oxidative damage products were doubled at high dose C:26 (79, 84). This evidence concerns the gene ABCD1 and X-linked adrenoleukodystrophy.