As given in Figures 3(b) and 3(c), compared with group A, the average number of AMPKα-positive staining cells in ESCC tissue of group B was extremely significantly reduced (P < 0.01), while the average number of STK11-positive staining cells was extremely significantly increased (P < 0.01). Here, STK11 is linked to esophageal squamous cell carcinoma.