These cells secrete a wide range of hormones and cytokines, including tumor necrosis factor-alfa (TNF-α), interleukin-1 beta (IL-1β), and macrophage chemoattractant protein- (MCP-) 1, which induces macrophage infiltration and low-grade inflammation that eventually results in a global impairment of glucose metabolism and insulin resistance [3]. Here, IL1B is linked to Insulin resistance.