In hematological malignancies such as leukemia, evasion from apoptosis is often achieved by systematic deregulation of two separate but related apoptotic signaling pathways: the intrinsic pathway is mainly controlled by BCL-2 family proteins and converges on the mitochondria [6], while the extrinsic pathway is activated by TNF family receptors such as death receptor 4 (DR4), death receptor 5 (DR5), or FAS upon receiving extracellular cues [7]. The gene discussed is TNFRSF10B; the disease is leukemia.