In vivo efficacy data obtained with TES-1025 in preclinical murine models of liver and kidney diseases (Katsyuba et al., 2018) suggested ACMSD as a promising novel therapeutic target to improve health in pathological settings such as that of acute kidney injury (AKI) (Kellum and Prowle, 2018; Manrique-Caballero et al., 2021). Here, ACMSD is linked to acute kidney injury.