As mentioned above, IL-15, IL-12, CTLA4, PD-1 and PD-L1 belong to immune-related molecules from ImmPort database (https://www.immport.org/resources) (Bhattacharya et al., 2018), and they have multiple effects on tumor development and immunotherapy (Arneth, 2019). This evidence concerns the gene CD274 and neoplasm.