Two patients in our center (case 1 and case 2) had various clinical syndromes involving CNS (encephalopathy and sleep disorders), PNS (pain), and autonomic 19 nervous system symptoms (hyperhidrosis, tachycardia, and hypertension) as well as serum and CSF LGI1 and CASPR2 antibodies. The gene discussed is LGI1; the disease is Encephalopathy.