Thus, in patients with eGFR ≥ 60 mL/min, the optimal cutoff point is a Gal-3 concentration of 19.7 ng/mL, whereas in patients with GFR < 60 mL/min/1.73 m2 is of 31.5 ng/mL, highlighting the importance of selecting Gal-3 values according to the existence of renal failure to improve the performance of this biomarker. The gene discussed is LGALS3; the disease is acute kidney injury.