After adjustment for age, sex, history of hypertension, diabetes and ischemic stroke, drinking, smoking, serum lipids (TC, TG, HDL-C, LDL-C), liver function indexes (AST, ALT, albumin, globulin), Cr, BUN and D-dimer, an FIB level ≥ 2.5 g/L was positively associated with combined CAD and cancer, while an HGB level ≥ 131 g/L was significantly associated with a low risk of combined CAD and cancer. The gene discussed is ALB; the disease is ischemic stroke.