Respiratory, digestive and urogenital cancers were significantly associated with a higher risk of CAD compared with no cancer (OR: 1.981, 95% CI: 1.236–3.175, p = 0.005; OR: 1.899, 95% CI: 1.177–3.064, p = 0.009; OR: 3.595, 95% CI: 1.696–7.620, p = 0.001), after adjustment for age, sex, drinking, smoking, history of hypertension, diabetes and stroke and HGB, TC, TG, HDL-C, LDL-C, AST, ALT, direct bilirubin, albumin, globulin, Cr, BUN, D-dimer and FIB levels. The gene discussed is CYGB; the disease is Stroke.