Cardiomyocyte-restricted inhibition of UCHL1 yields starkly different effects on post-MI hearts from the previously reported systemic UCHL1 inhibition; hence, it will be very interesting and important to investigate the effects of the inhibition of UCHL1 selectively in the non-cardiomyocyte compartments on post-MI remodeling and other cardiac disorders. This evidence concerns the gene UCHL1 and myocardial infarction.