UCHL1 and myocardial infarction: These findings are in stark contrast to a recent report which showed a protective effect of systemic UCHL1 inhibition by LDN-57444 against post-MI myocardial fibrosis and LV malfunction in mice (15), suggesting that inhibition of UCHL1 in the non-cardiomyocyte compartment or an off-target effect of LDN-57444 might play an important role in protecting the post-MI heart by this pharmacological compound.