UCHL1 and cardiac hypertrophy: To some extent, these findings are in contrast to the previously reported studies showing that systemic inhibition of UCHL1 using both genetic or pharmacological approaches significantly suppressed pressure-overloaded cardiac hypertrophy (20, 22), suggesting that the blood pressure reduction property of chronic systemic UCHL1 inhibition might have played a greater role in the observed suppression of cardiac hypertrophy than originally thought (22).