AKT1 and familial dilated cardiomyopathy: Beyond that, as Sen has reported that knockdown of OGDHL in SiHa cells would lead to AKT activation and increase nuclear factor kappa B (NF-κB) translocation and DNA binding (31), both of which are also the crucial signaling pathways for the apoptosis of cardiomyocytes and myocardial fibrosis (32), it could be hypothesized that OGDHL contributes to DCM fibrosis by regulating glutathione metabolism and followed AKT/NF-κB pathways.