The detected pathways included TGFB-, NOTCH-, FGF-, WNT-, Cadherin- and VEGF signaling pathways associated with EMT, Integrin- and HIF-1 signaling linked to ECM remodeling and NF-κB-, TNF-, osteoclast differentiation, Endothelin- and IL-17 signaling observed in aortic and mitral valve disease. This evidence concerns the gene TNF and mitral valve disorder.