Additional pathways identified as dysregulated included those related to cardiomyopathy, with gene overlap including Tgfb2, Thbs1 (thrombospondin-1, also known as Tsp-1), and Ace (Angiotensin I Converting Enzyme, or ACE), all of which code for factors previously implicated in both vascular and cardiac pathogenesis (46). The gene discussed is ACE; the disease is cardiomyopathy.