Triple-Negative Breast Cancers, forming 15% of the breast tumours (19), expresses characteristics of a basal-like subgroup of ductal cells, has a decreased expression of ER, PR and Her2,increased expression of proliferative markers (20), greater chances of late re-lapses (21), and molecular pathophysiology that remains poorly understood even today (22). Here, ESR1 is linked to triple-negative breast carcinoma.