Studies have shown that miR-27a-3p in EVs secreted by MSCs can promote the transformation of bone marrow-derived macrophages (BMDM) to M2 type, and inhibit the expression of alveolar macrophages NF-kB subunit 1, thereby inhibiting the NF-kB signaling pathway and alleviating the progression of ARDS (Wang et al., 2020). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.