For instance, miRNA-223 negatively regulates the TLR4/NF-kB pathway in macrophages and the activation of nucleotide-binding oligomerization like receptor 3 (NLRP3) inflammasome, attenuating lipopolysaccharide (LPS)−induced inflammation in ALI (Wang et al., 2015; Yan et al., 2019). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.