The siRNAs in EVs can target the human epidermal growth factor receptor 2(HER2)mRNA in HEK-293T, exerting the inhibitory effect of siRNAs silencing, and inhibiting the expression of HER2, which plays an important role in the treatment of HER2+ breast cancer (Lamichhane et al., 2016). The gene discussed is ERBB2; the disease is breast carcinoma.