Studies have shown that EVs containing high levels of syndecan-1 can exert anti-inflammatory effects through the FAK/p190RhoGAP/RhoA/ROCK/NF-kB signaling pathway, and protect organs, thereby exerting a protective effect in the occurrence and development of ARDS (Zhang C. et al., 2019). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.