AKT1 and gastric cancer: Sgc-7901 xenograft tumor model showed that Valproic acid (2-propylpentanoic acid, VPA) could inhibit histone deacetylase 1/2(HDAC1/2) activity and induce autophagy in gastric cancer cells, which can further inhibit the HDAC1/PTEN/Akt signaling pathway as well as regulate Bclin-1 and Beclin-2 (Sun et al., 2020).