One study was conducted in healthy subjects after the administration of single oral brexpiprazole doses (28), the second study assessed D2/D3 receptor occupancy as well as 5-HT1A, 5-HT2A and serotonin transporter (SERT) occupancies in a total of 12 patients with schizophrenia after 10 days treatment (27). This evidence concerns the gene HTR1A and schizophrenia.