MAPT protein (the hallmark pathology in Alzheimer’s disease) aggregation inhibits the expression of IST1 through the CEBPB-ANP32A-INHAT pathway, which hinders the formation of the ESCRT-III complex, inhibits the fusion of autophagosomes and lysosomes, and leads to autophagy disorder (Feng et al., 2020). The gene discussed is CEBPB; the disease is early-onset autosomal dominant Alzheimer disease.