Furthermore, MKRN1 stimulates p21 ubiquitination and proteasome pathway degradation to down-regulate p21 expression, decreasing IH-induced ROS generation and myocardial apoptosis, providing a novel target for lowering cardiovascular risk in obstructive sleep apnea (OSA) patients (48). The gene discussed is MKRN1; the disease is obstructive sleep apnea syndrome.