For patients undergoing radical radiotherapy, cluster 2 had significantly higher level of CD8+ T cells (p = 0.002), neutrophils (p <0.001), macrophages (p <0.001), dendritic cells (p <0.001), stromal score (p <0.001), immune score (p <0.001), and estimate score (p <0.001), but showed lower level of tumor purity than cluster 1 (p <0.001) (Figure 3D). This evidence concerns the gene CD8A and neoplasm.