The deletion of TP53, a tumor suppressor gene, can regulate mitochondrial respiration by promoting the Warburg effect in cancer cells, while increase the uptake of glucose in cancer cells through the repression of transcription of glucose transporter (GLUT) isoforms 1 and 4 and inhibition of the expression of glycolytic enzymes (82–85).TP53 gene improves the fidelity of DNA replication and homologous recombination through transcriptional activation of mismatch repair (MMR) genes. The gene discussed is TP53; the disease is cancer.