Recent findings suggest an impaired immunosurveillance in BCC that show a reduced major histocompatibility complex I (MHC-I) expression with a low CD4+ and CD8+ T-cell infiltration and an increase in regulatory T-cell (Treg) infiltration with an uprise in interleukins and cytokines that promote immunosuppression (13, 14). The gene discussed is CD4; the disease is skin basal cell carcinoma.