It is worth noting that circMRPS35 can not only adsorb miR-148a-3p, regulate the expression of Syntaxin 3 (STX3), thereby regulating the ubiquitination and degradation of phosphatase and tensin homolog (PTEN) but can also encode a peptide (circMRPS35-168aa), this peptide promotes cisplatin resistance in HCC cells. Here, STX3 is linked to hepatocellular carcinoma.