ESR1 and liver cancer: In summary, PADP may up regulate genes ESR1, AR, and down regulate genes CCNB1, CDK1, AKR1C3, and CCNA2, through p53 signaling pathway, IL-17 signaling pathway, TNF signaling pathway and Toll-like receptor signaling pathway, thereby promoting the apoptosis of liver cancer cells, shortening the cell cycle, and inhibiting the proliferation and invasion of liver cancer cells.