In summary, PADP may up regulate genes ESR1, AR, and down regulate genes CCNB1, CDK1, AKR1C3, and CCNA2, through p53 signaling pathway, IL-17 signaling pathway, TNF signaling pathway and Toll-like receptor signaling pathway, thereby promoting the apoptosis of liver cancer cells, shortening the cell cycle, and inhibiting the proliferation and invasion of liver cancer cells. This evidence concerns the gene AKR1C3 and liver cancer.