On the one hand, miR-1908-5p targets PTEN to promote the proliferation, invasion, and metastasis of osteosarcoma cells such as 143B, U2OS, MG63, and SAOS2 (9); on the other hand, miR-1908-5p can also target ROCK1 and inhibit the proliferation of osteosarcoma cells such as HOS, MG63, G293, SAOS2, and U2OS (38). Here, PTEN is linked to osteosarcoma.