AKT1S1 and non-small cell lung carcinoma: In a mildly hypoxic environment, miR-1908-5p targets AKT1S1 to up-regulate the expression of marker genes in the RP/p53/p21 signaling axis and inhibit the proliferation of NSCLC cells (including SK-MES-1, A549, and NCI-H460) (22).