CEACAM5 and neoplasm: As a result, the multivariable analysis defined CEA (HR, 2.102; 95% CI 1.318–3.071; p < 0.001), tumor differentiation (HR, 6.125; 95% CI 1.228–30.456; p = 0.027), N stage 8th (HR, 6.077; 95% CI 0.680–54.274; p = 0.036), after-operation therapy (HR, 0.474; 95% CI 0.315–0.713; p < 0.001), Local LN metastasis (HR, 0.938; 95% CI 0.852–1.291; p = 0.041), Liver Metastasis only (HR, 0.881; 95% CI 0.709–1.093; p = 0.039), and Multiple Metastases (HR, 0.434; 95% CI 0.335–0.561; p < 0.001) as independent prognostic factors of PPS (Table 2).