SET Domain, Bifurcated 1 (SETDB1) catalyzes the trimethylation of histone H3K9 (H3K9me3) and thereby promotes transcriptional silencing (65), the N-terminal of SETDB1 interacts directly with the plant homeodomain of DNMT3A and localizes to a silent promoter in cancer cells (66). Here, SETDB1 is linked to cancer.