LDHA and neoplasm: The radiosensitizing effects of the Hsp90 inhibitor NVP-AUY922 was studied using murine (B16F10) and human (LS174T) wildtype (WT) and CRISPR/Cas9 lactate dehydrogenases A/B (LDH−/−) double knockout tumor cells with an impaired lactate metabolism (6, 15).