LDHA and cancer: Our laboratory has previously demonstrated that a pharmacological inhibition of the lactate dehydrogenase (LDH) as well as a lactate dehydrogenase A/B (LDHA/B) double knockout (LDH−/−) has the capacity to decrease the expression of Hsp90, Hsp70 and Hsp27 and thereby can increase the radiosensitivity in cancer cells (6).