Different from TP53 and CTNNB1 mutations in classic HCC, fibrolamellar carcinoma frequently harbors DNAJB1-PRKACA fusion transcript (except for patients with Carney syndrome), and scirrhous carcinoma was reported to be associated with TSC1/TSC2 mutations (39, 41, 42). Here, TSC2 is linked to scirrhous adenocarcinoma.