If SIRT6 expression is increased, autophagy can be inhibited by inhibiting anaerobic glycolysis, which is conducive to disease treatment (77).Cyclosporine A inhibits neutrophil migration and apoptosis by inhibiting SIRT6, promoting the upregulation of HIF-1α expression and enhancing glycolysis and the TCA cycle, which is conducive to the remission of acute severe ulcerative colitis (78). Here, SIRT6 is linked to ulcerative colitis.