One explanation for the lack of development of ccRCC in mice by sole knockdown of Vhl is that the mouse Vhl gene is located on chromosome 6 while Pbrm1 and Bap1 are located on chromosome 14 and Setd2 is located on chromosome 9 (Figure 3). The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.