Moreover, upregulation of cancer-specific isoforms of TP73, CDH17, KLF6, FGFr2, FGFR3, DNMT3b3, and OPN has been reported in human hepatocellular carcinoma (HCC) and promoted cell cycle progression, proliferation, invasion and metastasis (22). The gene discussed is FGFR3; the disease is hepatocellular carcinoma.