Moreover, upregulation of cancer-specific isoforms of TP73, CDH17, KLF6, FGFr2, FGFR3, DNMT3b3, and OPN has been reported in human hepatocellular carcinoma (HCC) and promoted cell cycle progression, proliferation, invasion and metastasis (22). This evidence concerns the gene SPP1 and hepatocellular carcinoma.