DRD2 and neoplasm: It was reported that the DRD2 on cell membrane could exert anti-tumor effects by down-regulating eEF1A2 (40), while the eEF1A2 could promote the proliferation, migration, and invasion of OS cells by activating the Akt/mTOR signaling pathway (41), which implies that DRD2 has the anti-OS effect.