On the other hand, the tissue expressions of VEGF-D and VEGFR-3 by IHC did not correlate with any clinicopathological characteristics, as demonstrated by a previous study showing a positive IHC staining for VEGF-D and VEGFR-3 in 100% and 90% of VSCC cases, respectively, and no correlation with the presence of lymph node metastases (17). This evidence concerns the gene FLT4 and metastatic malignant neoplasm in the lymph nodes.