The overexpression of Epidermal Growth Factor Receptor (EGFR), Erb-B2 Receptor Tyrosine Kinase 2 (HER2), and Vascular Endothelial Growth Factor Receptor (VEGFR) has been reported in esophageal cancer, which enhances tumor occurrence, progression, and drug resistance. The gene discussed is EGFR; the disease is neoplasm.