F. nucleatum is probably involved in tumorigenesis due to the presence of bacterial proteins FadA and Fap2 because bacterial FadA causes tumor formation by activating the WNT/catenin beta 1 signaling pathway, and Fap2 can inhibit NK cells and T cell signaling through binding to the immunoreceptor tyrosine-based inhibition motifs (ITIMs) (163–165). The gene discussed is CTNNB1; the disease is neoplasm.