Several cellular signaling pathways that regulate cell proliferation, differentiation, apoptosis, and survival are involved in CRC onsets, such as epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK), Wingless-related integration site (Wnt)/β-catenin, phosphoinositide 3-kinase (PI3K), transforming growth factor-β (TGF)-β, Neurogenic locus notch homolog protein (Notch), and nuclear factor (NF)-κB (10). Here, PIK3CA is linked to colorectal carcinoma.