Several blood-based biomarkers, such as cancer antigen 19-9, serum tissue polypeptide-specific antigen (TPS) and tissue polypeptide antigen (TPA), cytokeratin 8, 18 and 19, as well as Kininogen-1 (KNG1) were all identified as potentially useful biomarkers for both early detection and prognostic purposes in CRC (83, 84). Here, KNG1 is linked to colorectal carcinoma.