TP53 and neoplasm: (i) the better degree of fixation of biopsies(ii) the early knowledge of p53 status in a pre-operative settingThe main advantages of performing IHC on surgical sample are the following:(i) larger amount of tumoral representative tissue; (ii) the possibility to select the best specimen for IHC testing; (iii) the possibility to overcome tumor heterogeneity.- The presence of an internal positive control is mandatory for interpretation of results.- Move to genetic testing as a confirmatory test or whenever there is any doubt in IHC interpretation.