In endometrial cancer, the copy-number high/serous-like group is characterized by low mutational rate (2.3 × 10−6 mutation per megabase) but extensive SCNA somatic copy-number alteration (SCNA), with TP53 mutation in 90% of cases (17).The copy-number high/serous like group mainly includes high-grade tumors, in particular SECs and UCSs. The gene discussed is TP53; the disease is endometrial cancer.