IL1B and chronic obstructive pulmonary disease: Figure 7(c) shows the IL-6 expression level result graph, and Figure 7(d) shows the NF-kB expression level result graph. The expression of TNF-a, IL-1β, IL-6, and NF-KB in COPD and COPD+anti-miR-149-3p group were higher than control group, and TNF-a, IL-1β, IL-1, and NF-KB level in COPD+anti-miR-149-3p group was higher than COPD group. Compared with the control group, the expressions of TNF-α, IL-1β, IL-6, and NF-kB in the alveolar lavage fluid of the model group were statistically poor (P < 0.05).