For epilepsy, there were 11 genes differentially expressed in any one of the epilepsy-related GEO series with statistical significance (P < 0.05/n, n ≤ 69, Bonferroni corrected for the number of genes that appears in each GEO data set), including CABP1, CD3G, ERBB4, FRAT1, KLHDC8B, RPL5, SLCO3A1, SPI1, UBE4A, ZDHHC8, and ZSCAN31. Four out of the 11 genes presented more than 2-fold changes (absolute log2 fold change >1), with 2 upregulated genes (CABP1 and ZDHHC8) and 2 downregulated ones (ERBB4 and ZSCAN31). The gene discussed is SPI1; the disease is epilepsy.