In the GEO data sets of depression, we observed the upregulation of 2 genes (CAMTA1 and SLCO3A1) as well as the downregulation of 6 other genes (CD3G, CSMD1, CTTNBP2, CUL4A, PSEN2, and SLC39A13). The gene discussed is CUL4A; the disease is depressive symptom measurement.