CXCL8 and neoplasm: Furthermore, it has also been found that extracellular lactic acid, the catalytic products of LDH, stimulates vascular endothelial cells to express inflammatory factor IL-8 and vascular endothelial growth factor in tumor study (23–26), which possibly promote local inflammation and angiogenesis, contributing to the BBB destruction and cerebral edema in ischemic stroke.