Furthermore, it has also been found that extracellular lactic acid, the catalytic products of LDH, stimulates vascular endothelial cells to express inflammatory factor IL-8 and vascular endothelial growth factor in tumor study (23–26), which possibly promote local inflammation and angiogenesis, contributing to the BBB destruction and cerebral edema in ischemic stroke. This evidence concerns the gene VEGFA and ischemic stroke.