As shown in Figure 3(a), mice exposed to 10% acetic acid-induced gastric ulcer recurred by IL-1β administration and treated with vehicle showed a unique gastric lesion compatible with ulcers morphology in an extension of 6.8 ± 0.9 mm2 at the 15th day after the ulcer induction, indicating recurrence of the lesion because there was no ulcerative lesion in the gastric mucosa in ulcerated mice that did not receive IL-1 3β on the same day after ulcer induction. Here, IL1B is linked to ulcer disease.