NFKB1 and cerebral infarction: However, in transient and permanent cerebral ischemia models, specific or nonspecific NF-κB inhibitors could significantly reduce the area of cerebral infarction and improve the neurological deficits [28, 29].This was further supported by our observations in the current study, in which we found that SNX significantly inhibited the level of NF-κB to decrease inflammation.