Specifically, we found that BSYSC may promote remyelination by promoting miR-219 or miR-338 expression in exosomes and recruit OPCs by inhibiting Sox6, Hes5, and Lingo1 expression, thus promoting OPCs differentiation and improving the ability of OPCs to wrap around axons to ultimately ameliorate MS. Here, LINGO1 is linked to myeloid sarcoma.