In-depth studies have revealed that miR-219 promotes OPCs differentiation and remyelination by inhibiting the transcription factors Hes5 and Lingo1 [77], which negatively regulate OPCs differentiation [78] The transcription factor Hes5 negatively regulates OPCs differentiation in EAE models [79] and is highly expressed in acute lesions in MS [80], suggesting that it plays a role in inhibiting oligodendrocyte differentiation and remyelination. This evidence concerns the gene HES5 and myeloid sarcoma.