Screening for methylation map changes in peripheral blood samples of women with presbycusis as compared to controls, P2RX2 (purinergic receptor P2 × 2), KCNQ5 (potassium voltage-gated channel subfamily Q member 5), ERBB3 (erb-b2 receptor tyrosine kinase 3), and SOCS3 (suppressor of cytokine signaling 3) have been associated with the progression of age-related hearing loss (8). The gene discussed is P2RX2; the disease is presbycusis.