Three autophagy-related genes (Dram1, Fkbp1b, and Fos) were differentially expressed in the mild hearing loss group, whereas five autophagy-related genes (Dram1, Fkbp1b, Fos, Capn2, and Eef2) were differentially expressed in the severe hearing loss group. The gene discussed is CAPN2; the disease is hearing loss disorder.