However, inconsistent directions between P2X7 and adipose tissue accumulation have been reported from experiments using P2X7-deficient or diet-induced obesity mouse models (Sun et al., 2012; Beaucage et al., 2014; Buzzetti et al., 2016; Blasetti Fantauzzi et al., 2017; Giacovazzo et al., 2018). Here, P2RX7 is linked to obesity due to melanocortin 4 receptor deficiency.