MGluR4PAM in several animal models of PD, a positive allosteric modulator of mGluR4 (VU0364770), elicits significant antiparkinsonian effects, but it fails to affect the development and evolution of LID in unilaterally 6-OHDA-lesioned rats (Iderberg et al., 2015; Tison et al., 2016). The gene discussed is GRM4; the disease is Parkinson disease.