PRDM16 and obesity due to melanocortin 4 receptor deficiency: Hasegawa et al. (2018) found that GTF2IRD1 inhibits obesity-related adipose tissue fibrosis in humans and mice by recruiting PRDM16 and Ehmt1 into the promoter or enhancer region of the growth suppressor β gene, improving glucose metabolism and homeostasis (Hasegawa et al., 2018).