Yang et al., 2016 found that the activation of AMPK by AICAR or metformin can rescue obesity-induced brown fat production and thermogenesis inhibition, which may be related to the AMPK-α1/αKG/PRDM16 signaling pathway (Yang et al., 2016). The gene discussed is PRDM16; the disease is obesity due to melanocortin 4 receptor deficiency.