Dietary addition of capsaicin promoted WAT browning to fight obesity but did not prevent obesity in TRPV1−/− mice, suggesting that activation of the TRPV1 pathway promotes the interaction between PPARγ and PRDM16 protein to protect against obesity (Baskaran et al., 2016). Here, TRPV1 is linked to obesity due to melanocortin 4 receptor deficiency.