Gan et al. (2018) proposed that Foxc2 ameliorates inflammation and promotes fat browning in high-fat diet (HFD)-induced obese mice by reducing the leptin-mediated JAK2/STAT3/PRDM16 pathway (Gan et al., 2018). In addition, Zhang et al. (2019) found that ciRS-133 knockout reduced the occurrence of cachexia, increased the expression of PRDM16 in tumor tissues, and decreased oxygen consumption and heat production (Zhang et al., 2019). Here, PRDM16 is linked to Cachexia.