A study by (Goryachkina et al., 2008) revealed that IMs, but not NMs, developed postural hypotension and severe bradycardia during combination treatment with metoprolol and paroxetine, indicating that patients with lower CYP2D6 enzyme activity after the administration of strong CYP2D6 inhibitors are more likely to phenotypically convert to CYP2D6 PMs than those with normal enzyme activity. This evidence concerns the gene CYP2D6 and hypotensive disorder.