The expression of PAI-1 was increased in the prefrontal cortex and hippocampus of the chronically stressed rats (Tang et al., 2015), suggesting that PAI-1 up-regulation may play a key role in the pathological process of depression (Tang et al., 2015; Jiang et al., 2016; Han et al., 2019). Here, SERPINE1 is linked to depressive disorder.