Abnormal expression of human leukocyte antigen -DR (HLA-DR) on fibroblasts is associated with the development of GO (Heufelder et al., 1991; Hiromatsu et al., 1995), and it has been reported that the expression of various adhesion molecules (e.g., ICAM-1) on orbital fibroblasts (RFs) is involved in the migration of lymphocytes to the site of orbital inflammation. The gene discussed is ICAM1; the disease is geroderma osteodysplastica.