TSHR and Jeune syndrome: What’s more, these new treatments are mostly targeting the upstream and downstream of the abnormal activation of TSHR to reduce the abnormal thyroid hormone secretion, and lacking relevant research and treatment strategies for abnormal hyperplasia and hypertrophy of thyroid follicular epithelial cells, accumulation of orbital adipose cells and formation of lipid drops in patients with GO, hyper sweating, palpitations, zygomatic redness, irritability, impaired liver function and anaphylactic reaction towards ATD.